EAN Research Paper of the month – May 2025
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High-Dose Vitamin D Reduces Disease Activity in Early MS | JAMA Neurology
The D-Lay MS trial, a multicentre, double-blind randomised clinical study, assessed the effect of high-dose vitamin D on disease activity in patients with clinically isolated syndrome (CIS) typical for multiple sclerosis (MS). A total of 316 participants were randomised 1:1 to receive 100,000 IU oral cholecalciferol or placebo every two weeks for 24 months. The primary analysis included 303 patients (163 vitamin D, 153 placebo), with a median age of 34 years (IQR 28–42), of whom 70% were women.
Quantitative MRI Detects Occipital Cortical Inflammation in Migraine With Aura | Annals of Neurology
This large cross-sectional study applied a novel, multimodal MRI protocol to investigate cortical inflammation in migraine, focusing on differences between migraine with and without aura. A total of 296 adults with migraine (103 with aura, 180 with chronic migraine, 88 scanned during an attack) and 155 age- and sex-matched healthy controls underwent imaging using T2, T1, and ADC mapping to assess tissue water content, microstructural integrity, and oedema.
GLP-1 and SGLT2 Inhibitors Linked to Lower Dementia Risk in Type 2 Diabetes | JAMA Neurology
In this large emulated trial, the authors recruited more than 90,000 patients using electronic health record data from the OneFlorida+ Clinical Research Consortium to compare the risk of Alzheimer’s disease (AD) among individuals aged ≥50 with type 2 diabetes. They identified individuals who initiated treatment with a GLP-1 receptor agonist (GLP-1RA), an SGLT2 inhibitor (SGLT2i) and compared them to those starting another second-line glucose-lowering drug (GLD). The outcome was a diagnosis of AD using diagnostic coding algorithms.
For further details of these Research Papers and to view the links to the papers publications click the link here to the May EAN Research Highlights page
