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Prof. Michael Hutchinson

Adult Neurology, Neuropharmacology

Consultant Neurologist and Newman Clinical Research Professor

St. Vincent"s University Hospital,
Elm Park,
Dublin 4

St. Vincent

Paula Halpin

Adult Neurology, Neuropharmacology

Research with
1) Dr Paula Byrne, Senior Lecturer, Dept of Pathology, Conway Institute, UCD.
2) Professor Susan B.Bressman, MD, Chair, Dept of Neurology, Albert Einstein College of Medicine
Phillips Ambulatory Care Center, 10 Union Square East, New York, NY 10003
3) Laurie Ozelius, Ph.D. Associate Professor, Molecular Genetics Department
Albert Einstein College of Medicine, Ullmann 1211, 1300 Morris Park Ave.
Bronx, NY 10461

Recent Publications from 2004 to April 2006.
Polman CH, O"Connor PW, Havrdova E, Hutchinson M, Kappos L, Miller DH, Phillips JT, Lublin FD, Giovannoni G, Wajgt A, Toal M, Lynn F, Panzara MA, Sandrock AW, for the AFFIRM Investigators. A Randomized, Placebo-Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis. N Eng J Med 2006; 354:899-910.
Cunningham S, Graham C, Hutchinson M, Droogan A, O"Rourke K, Patterson C, McDonnell G, Hawkins S, Vandenbroeck K. Pharmacogenomics of responsiveness to IFN-¥â treatment in multiple sclerosis: A genetic screen of 100 Type I IFN-inducible genes. Clinical Pharmacology and Therapeutics (2006, in press)
O"Rourke K, O"Riordan S, Gallagher J, Hutchinson M. Paroxysmal torticollis and blepharospasm following bilateral cerebellar infarction. J Neurol 2006 (in press)
Williams J, O"Rourke K, Hutchinson M, Tubridy N. The Face-Symbol Test and the Symbol-Digit Test are not reliable surrogates for the Paced Auditory Serial Addition Test in multiple sclerosis. Multiple Sclerosis 2006 (in press)
McGuigan C, Hutchinson M. Unrecognised symptoms of depression in a community-based population with multiple sclerosis. J Neurol 2006;253:219-223.
Kinirons P, Caily C, De Gascun C, Hutchinson M. Lymphocytic meningitis: incidence, causes and outcomes over five years. Ir Med J 2005;98:238-240.
Hutchinson M. The management of Bell"s Palsy. Ir Med J 2005;98:165.
McGuigan C, Dunne C, Crowley J, Hagan R, Rooney G, Lawlor E, Hutchinson M. Population frequency of HLA haplotypes contributes to the prevalence difference of MS in Ireland. J Neurol 2005;252:1245-1248.
Kinirons P, O"Dwyer JP, Connolly S, Hutchinson M. Paraneoplastic limbic encephalitis presenting as lingual epilepsia partialis continua. J Neurol 2006;253:256-257.
O"Dwyer JP, O"Riordan S, Saunders-Pullman R, Bressman SB, Molloy FM, Lynch T, Hutchinson M. Sensory abnormalities in unaffected relatives in familial adult onset dystonia. Neurology 2005;65:938-940.
Ryan A, Molloy FM, Farrell MA, Hutchinson M. Fatal toxic leukoencephalopathy: clinical, radiological, and necropsy findings in two patients J Neurol Neurosurg Psychiatry 2005;76:1014-16.
O"Dwyer JP, Clabby C, Crown J, Barton DE, Hutchinson M. Fragile-X-associated tremor/ataxia syndrome presenting in a woman after chemotherapy. Neurology 2005; 65:331-2.
O"Rourke KET, Hutchinson M. Stopping beta-interferon therapy in multiple sclerosis.: an analysis of stopping patterns. Multiple Sclerosis 2005;11: 46-50.
O"Riordan S, Ozelius LJ, de Carvalho Aguiar P, Hutchinson M, King M, Lynch T. Inherited myoclonus- epilepsy: further evidence of an association? Mov Disord 2004;19:1456-59.
O"Riordan S, Raymond D, Lynch T, Saunders-Pullman R Bressman SB, Daly L, Hutchinson M. Age at onset as a factor in determining the phenotype of primary torsion dystonia. Neurology 2004;63:1423¢®V1426
O"Riordan S, Lynch T, Hutchinson M. Familial adolescent-onset scoliosis and later segmental dystonia in an Irish family. J Neurol 2004;251:845-8.
McGuigan C, Hutchinson M. Confirming the validity and responsiveness of the Multiple Sclerosis Walking Scale-12 (MSWS-12). Neurology. 2004;62:2103-5.
Vukusic S, Hutchinson M, Hours M, Moreau T, Cortinovis-Tourniaire P, Adeleine P, Confavreux C, The Pregnancy In Multiple Sclerosis Group; Pregnancy In Multiple Sclerosis Group. Pregnancy and multiple sclerosis (the PRIMS study): clinical predictors of post-partum relapse. Brain. 2004;127:1353-60.
McGuigan C, McCarthy A, Quigley C, Bannan L, Hawkins SA, Hutchinson M. Latitudinal variation in the prevalence of multiple sclerosis in Ireland, an effect of genetic diversity. J Neurol Neurosurg Psychiatry. 2004;75:572-6.
O"Riordan S, Hutchinson M. Cervical dystonia following peripheral trauma - a case-control study. J Neurol. 2004;251:150-5.
Horan G, Keohane C, Molloy S, Howley R, Harney M, Heffernan J, McGuigan C, Hutchinson M, Brett F, Farrell M. Creutzfeldt-Jakob disease in Ireland: epidemiological aspects 1980-2002. Eur Neurol. 2004;51:132-7.
McGuigan C, Hutchinson M. The multiple sclerosis impact scale (MSIS-29) is a reliable and sensitive measure. J Neurol Neurosurg Psychiatry. 2004;75:266-9.
McMonagle P, Byrne P, Hutchinson M. Further evidence of dementia in SPG4-linked autosomal dominant hereditary spastic paraplegia. Neurology. 2004;62:407-10.